Regulation of 11 -hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol
نویسندگان
چکیده
Elise P. Gomez-Sanchez,1,2,4 Venkataseshu Ganjam,5 Yuan Jian Chen,5 Ying Liu,4 Ming Yi Zhou,4 Cigdem Toroslu,4 Damian G. Romero,2 Michael D. Hughson,3 Angela de Rodriguez,2 and Celso E. Gomez-Sanchez1,2,4 1Endocrine Section and Research Service, G. V. (Sonny) Montgomery Veterans Affairs Medical Center, 2Division of Endocrinology, and 3Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi 39216; and Departments of 4Medicine and 5Veterinary Biomedical Sciences, University of Missouri-Columbia, Columbia, Missouri 65211
منابع مشابه
Effect of Pimpinella tirupatiensis on Oxidative Enzymes in STZ-induced Diabetic Rat Kidney
The present study was aimed to evaluate the therapeutic potential of Pimpinella tirupatiensis (Pt) by assaying the activities of selective mitochondrial enzymes in streptozotocin induced diabetic rats. Diabetic rats showed a significant (p < 0.01) reduction in the activities of oxidative enzymes Succinate dehydrogenase (SDH), Malate dehydrogenase (MDH), Glutamate dehydrogenase (GDH) and isocitr...
متن کاملRegulation of 11 beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol.
The 11beta-hydroxysteroid dehydrogenase (11betaHSD) type 1 (11betaHSD1) enzyme is an NADP+-dependent oxidoreductase, usually reductase, of major glucocorticoids. The NAD+-dependent type 2 (11betaHSD2) enzyme is an oxidase that inactivates cortisol and corticosterone, conferring extrinsic specificity of the mineralocorticoid receptor for aldosterone. We reported that addition of a reducing agent...
متن کاملEffect of Pimpinella tirupatiensis on Oxidative Enzymes in STZ-induced Diabetic Rat Kidney
The present study was aimed to evaluate the therapeutic potential of Pimpinella tirupatiensis (Pt) by assaying the activities of selective mitochondrial enzymes in streptozotocin induced diabetic rats. Diabetic rats showed a significant (p < 0.01) reduction in the activities of oxidative enzymes Succinate dehydrogenase (SDH), Malate dehydrogenase (MDH), Glutamate dehydrogenase (GDH) and isocitr...
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Background: Aqueous extract of winter cherry (Physalis alkekengi L; family of Solanaceae) fruits (WCF) has long been recommended for fertility control by herbalists in Iran. The effect of this extract on lowering serum progesterone levels has been reported previously. Objective: To study the effects of WCF extract on the activities of ovarian 3β-hydroxysteroid dehydrogenase (3β-HSD) responsible...
متن کاملRenal medullary 11 beta-hydroxysteroid dehydrogenase type 1 in Dahl salt-sensitive hypertension.
The Dahl salt-sensitive rat is a widely used model of human salt-sensitive forms of hypertension. The kidney plays an important role in the pathogenesis of Dahl salt-sensitive hypertension, but the molecular mechanisms involved remain a subject of intensive investigation. Gene expression profiling studies suggested that 11 beta-hydroxysteroid dehydrogenase type 1 might be dysregulated in the re...
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